In Pharmacogenomics, Next Generation Sequencing Is Extensively Used To Accelerate Drug Discovery

Next Generation Sequencing 



The order of the nucleotides in the entire genome can be determined using Next Generation Sequencing (NGS), a massively parallel sequencing method that offers scalability, ultra-high throughput, and fast speed. As it includes preparing the material for the subsequent sequencing reaction, DNA pre-sequencing is one of the most important processes in the overall sequencing protocol.

Globally, NGS is being gradually included into clinical laboratory analysis, testing, and illness diagnosis. Pharmacogenomics has made extensive use of Next Generation Sequencing to quicken the drug discovery process.It is further divided into categories based on consumables for sample preparation and other purposes. Consumables for DNA fragmentation, end repair, A-tailing and size selection, library preparation & target enrichment, and quality control are further divided under the sample preparation category.

The process of determining the precise arrangement of nucleotides inside a DNA molecule is known as Next Generation Sequencing. Using a next-generation sequencer, next-generation sequencing enables quick sequencing and generates a million DNA and RNA sequences. The next generation of sequencing has a high throughput.

The term "next generation sequencing" refers to a number of contemporary sequencing techniques, including Roche 454 and Illumina. Comparing next-generation sequencing to the more traditional Sanger's sequencing approach, it is less expensive and provides a higher throughput for DNA sequencing.Applications for Next Generation Sequencing are found in the study of genetic disorders, neonatal sequencing, metagenomics, personalised medicine, the search for biological drugs, agricultural research, animal research, and cancer research.

Another use for next-generation sequencing is the identification of binding sites on transcriptional factors, as well as the expression profiling of non-coding RNA and re-sequencing of targets. Due to numerous technical and functional advancements, high-throughput sequencing, also known as Next Generation Sequencing is now incorporated into routine clinical practise. Earlier protocols relied on samples collected outside of typical clinical pathology workflows, standard formalin-fixed, paraffin-embedded specimens, which can be used more frequently as starting material for NGS. Also being developed are methods for the processing and interpretation of NGS data as well as knowledge bases, which will make it simpler for physicians to use genomic data when treating patients.

The requirement of healthcare institutions is being met by the availability of a wide range of next-generation sequencing products for the diagnosis of chronic disorders.High-throughput sequencing is another name for Next Generation Sequencing (NGS). Rapid base pair sequencing of DNA or RNA materials is made possible by NGS. Personalized medicine, genetic illnesses, and clinical diagnostics are all being advanced by NGS. The NGS products, however, have been divided into three major categories in this study: platforms, services, and consumables.

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