Fc Protein And Glycoengineered Antibodies Play A Crucial Role In Defending The Body Against Pathogens
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| Fc Protein And Glycoengineered Antibodies |
Fc Protein And Glycoengineered Antibodies that are found on the surface of immune cells such
as B cells and natural killer cells. The Fc portion of an antibody molecule is
the region that binds to receptors on other cells, and it is responsible for
initiating a wide range of immune responses. There are several different types
of Fc proteins, including IgG, IgA, and IgE, each of which has a different role
in the immune system.
IgG is the most abundant antibody in the human body
and is involved in fighting bacterial and viral infections. The Fc portion of
IgG antibodies can bind to a variety of receptors on other cells, including Fcγ
receptors on immune cells and FcRn receptors on endothelial cells. When IgG binds
to an antigen, it triggers a series of immune responses that help to eliminate
the pathogen.
Fcγ receptors are found on a variety of immune
cells, including macrophages, neutrophils, and natural killer cells. When IgG
binds to Fcγ receptors, it activates these cells and triggers the release of
inflammatory mediators such as cytokines and chemokines. This leads to an
influx of immune cells to the site of infection, where they can eliminate the
pathogen.
FcRn receptors are found on the surface of endothelial
cells in the blood vessels. When IgG binds to FcRn, it is protected from
degradation and has a longer half-life in the bloodstream. This is important
for maintaining a high concentration of antibodies in the blood and ensuring a
rapid immune response to any pathogens that enter the body.
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